Though rare, side effects of diosmin include stomach pain, diarrhea, headaches, dizziness, skin rash, hives, muscle pain, and — in severe cases — irregular heartbeat.
If you experience any side effects after taking diosmin, discontinue use and speak with your healthcare provider. If you experience severe pain, severe diarrhea, or an irregular heartbeat, seek medical attention immediately.
Dosage and how to take
Diosmin is available over the counter in the United States, Canada, and certain European countries. It’s typically sold as micronized purified flavonoid fraction (MPFF), which usually contains 90% diosmin and 10% hesperidin.
The most common and well-researched supplement is Daflon 500 (450 mg diosmin, 50 mg hesperidin). It’s also known as Detralex in some regions. However, many other diosmin products are likely available in your local pharmacy and online.
Most diosmin products recommend taking one 500-mg supplement with food once in the morning and again in the evening for a total of 1,000 mg per day.
Under the guidance of a health professional, these dosage guidelines have been shown to be safe and effective for various conditions:
Chronic venous disease: 1,000 mg per day for 3–6 months
Hemorrhoids: 1,000–2,000 mg per day for 4 days, followed by 1,000 mg per day for 3 days
Varicose veins: 1,000–2,000 mg per day for up to 6 months
Do not take diosmin for more than 3 months — or take more than the recommended dose on the label — unless instructed by your healthcare provider.
To date, there are no known cases of diosmin overdose or reports of toxicity.
Nonetheless, you should always follow the instructions on the label and speak to a healthcare professional to make sure it’s right for you.
Diosmin may interact with the following medications:
anticoagulants (such as Warfarin)
anticonvulsants (such as Carbamazepine and Phenytoin/Dilantin)
antihistamines (such as Allegra)
muscle relaxants (such as Chlorzoxazone)
non-steroidal anti-inflammatory drugs (such as Voltaren, Motrin, Advil, and Aleve)
acetaminophen (such as Tylenol)
Diosmin may inhibit various liver enzymes responsible for metabolizing the above medications. This can result in your medications working less effectively and may be dangerous for those with bleeding disorders by preventing proper blood clotting (34Trusted Source, 35Trusted Source, 36Trusted Source).
Diosmin may also interact with certain herbal supplements, including fenugreek, feverfew, garlic, ginger, ginkgo, ginseng, and turmeric, due to their involvement in blood thinning (34Trusted Source).
If you take any of these medications or supplements, be sure to speak to your healthcare provider before trying diosmin.